How Your Brain Works Against Weight-Loss

A study carried out in mice may help explain why dieting can be an inefficient way to lose weight: key brain cells act as a trigger to prevent us burning calories when food is scarce.

“Weight loss strategies are often inefficient because the body works like a thermostat and couples the amount of calories we burn to the amount of calories we eat,” says Dr Clémence Blouet from the Metabolic Research Laboratories at University of Cambridge. “When we eat less, our body compensates and burns fewer calories, which makes losing weight harder. We know that the brain must regulate this caloric thermostat, but how it adjusts calorie burning to the amount of food we’ve eaten has been something of a mystery.”