Aging

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Drug “reverses” ageing !

A drug that can reverse aspects of ageing has been successfully trialled in animals . . .  mice to be specific

They rejuvenated old mice (the equivalent of 90 in mouse years) to restore their stamina, coat of fur and even some organ function.

The findings, published in the journal Cell, showed liver function was easily restored and the animals doubled the distance they would run in a wheel.

Dr Peter de Keizer and the team at Erasmus University Medical Center, in the Netherlands, are planning human trials for what they hope is a treatment for old age.  (I’m signing up.  Always wanted to visit the Netherlands – the country, not the psychic-state)

The approach works by flushing out retired or “senescent” cells in the body that have stopped dividing. They accumulate naturally with age and have a role in wound healing and stopping tumours. But while they appear to just sit there, senescent cells release chemicals that cause inflammation and have been implicated in ageing.

The scientists created a drug that selectively killed senescent cells by disrupting the chemical balance within them.  The drug was given three times a week and the experiments took place for nearly a year.

“There are no signs of side-effects but “mice don’t talk”, Dr de Keizer said. “However, it is thought the drug would have little to no effect on normal tissues.”

(Mice talk, human’s just don’t understand “Mouselish”)

When asked if this was a drug for ageing, Dr Keizer told the BBC News website: “I hope so, but the proof of the pudding is in the eating as you say.  In terms of mouse work we are pretty much done, we could look at specific age-related diseases eg osteoporosis, but we should now prepare for clinical translation.”

Commenting on the results, Dr Dusko Ilic, a stem cell scientist at King’s College London, said: “The finding is impossible to dismiss.  [But] until more high-quality research is done, it is better to be reserved about these findings. Though, I would not be surprised if manufacturers try to capitalise on this and, in a few years, we could buy this peptide as a supplement over the counter.”

 

http://www.bbc.com/news/health-39354628

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The Longer Your Telomeres, The Longer You Live

“Telomeres – the caps at the end of our chromosomes – protect the DNA within our cells. The longer our telomeres, the less our likelihood of chronic disease and signs of aging.”

“Have you wondered why some sixty-year-olds look and feel like forty-year-olds and why some forty-year-olds look and feel like sixty-year-olds? While many factors contribute to aging and illness, Dr. Elizabeth Blackburn discovered a biological indicator called telomerase, the enzyme that replenishes telomeres, which protect our genetic heritage.”

“Dr. Blackburn and Dr. Elissa Epel’s research* shows that the length and health of one’s telomeres are a biological underpinning of the long-hypothesized mind-body connection. They and other scientists have found that changes we can make to our daily habits can protect our telomeres and increase our health spans (the number of years we remain healthy, active, and disease-free).”

“THE TELOMERE EFFECT* reveals how Blackburn and Epel’s findings, together with research from colleagues around the world, cumulatively show that sleep quality, exercise, aspects of diet, and even certain chemicals profoundly affect our telomeres, and that chronic stress, negative thoughts, strained relationships, and even the wrong neighborhoods can eat away at them.”

Lifestyle factors known to modulate aging and age-related diseases might also affect telomerase activity and have all been linked to shorter telomeres.

  • Obesity
  • Insulin resistance
  • Cardio-vascular disease processes (related to oxidative stress and inflammation)
  • Smoking
  • Exposure to pollution
  • Lower physical activity
  • Psychological stress
  • Unhealthy diet

You can counteract your “biological clock” by reactivating telomerase through diet and lifestyle interventions

With intensive lifestyle modification, a low fat diet, regular physical activity, and mental stress reduction (by yoga and meditation), telomerase activity increases significantly in peripheral blood mononuclear cell.

Specific nutrients provide all the necessary building blocks to support telomere health and extend lifespan like:

  • Folate 
  • Vitamins (B, D, E, C) 
  • Zinc
  • Polyphenol compounds such as resveratrol 
  • Grape seed extract 
  • Curcumin

Rich in those vitamins and minerals and a good source of antioxidants are foods like: Tuna, salmon, herring, mackerel, halibut, anchovies, cat-fish, grouper, flounder, flax seeds, sesame seeds, kiwi, black raspberries, green tea, broccoli, sprouts, red grapes, tomatoes and olives.  “These, combined with a Mediterranean type of diet containing fruits, vegetables and whole grains would help protect our chromosome ends [62–70].”

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4761710/

*The Telomere Effect,  A Revolutionary Approach to Living Younger, Healthier, Longer by Dr. Elizabeth Blackburn, Dr. Elissa Epel “A groundbreaking book coauthored by the Nobel Prize winner who discovered telomerase and telomeres’ role in the aging process and the health psychologist who has done original research into how specific lifestyle and psychological habits can protect telomeres, slowing disease and improving life.”

 

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What hallucination reveals about our minds

In the last weeks of my father’s life he told me about a man who would come into his house at night and lay down in the bed next to him.  Frightened, he would call the authorities.  

It was the first of many hallucinations, some benign, many terrifying, he experienced before he passed.  I learned it was futile to try to convince him that what he saw hadn’t been real.  I wish I had heard this TedTalk to help me better understand what was happening.

Oliver Sacks has passed but his experiences, wisdom and compassion remains with us in his talks and books.  You might know about him from Robin Williams portrayal in the Movie Awakenings.  Take a look and listen to Dr. Sacks’ TedTalk:

“Neurologist and author Oliver Sacks brings our attention to Charles Bonnet syndrome — when visually impaired people experience lucid hallucinations. He describes the experiences of his patients in heartwarming detail and walks us through the biology of this under-reported phenomenon.”

 jw