Did you know . . .Mice make faces too?

Eek! Mice make facial expressions based on their emotional state. (We’re not making this up.)

Mice make different faces depending on how they feel — and that could impact how we treat mood disorders

Mice, unlike most people, cannot force a smile or disguise their disgust (as far as we know). Most of us may not have realized that their tiny, fuzzy faces can muster an emotional expression at all.


But a group of German neurobiologists have proven mice can, in fact, express emotions — and they play out all over their petite faces. The researchers say that analyses of rodent brains in mid-emotional reaction could improve the ways we treat human patients with mood disorders.

“Being able to measure the emotion state of an animal can help us identify the ‘how’ and ‘where’ in the brain, and hopefully get hints at how emotions arise in humans, too,” *


Researchers carried out a series of experiments with emotive mice and linked five emotional states — pleasure, disgust, nausea, pain and fear — to their facial expressions.
The results, published  in the journal Science, could advance how we understand emotions — and they’re cute to boot.


How do you measure a mouse’s emotions?
It’s not easy.

First, the team stimulated mice to react in certain ways so they could observe how their faces changed.

  • Drinking a sweet solution evoked pleasure
  • drinking a bitter substance elicited disgust.
  • A painful shock to the tail could incite fear,
  • an injection of lithium chloride might have made them feel ill.

Not every mouse reacted the same way to the same stimuli, the researchers noted:

  • A thirsty mouse expressed pleasure when drinking water more than a full mouse did. That’s a fairly nuanced reaction for such a small animal.
  • Close-up footage of the mice showed subtle changes in their facial expressions:
  • When a mouse experienced pain, their noses drooped and their ears flicked down. When a mouse felt fearful, their ears ticked up and their eyes widened.

    Observations alone couldn’t determine the intensity of those emotions, though. So the neurobiologists next built descriptors for what each facial expression would look like and trained a computer to detect them in under a second. This effectively “measured” the emotions.


“But emotions don’t arise just in response to stimuli, the researchers noted — they originate in the brain.
So the neurobiologists took a peek inside the mice’s heads using two-photon imaging, a type of microscopy that can penetrate tissue to show how living cells move and change. The team used light to activate neurons, nerve cells that transmit information from the environment throughout the body to cause a mouse to react.”
The regions of the brain associated with emotions in humans lit up in mice, too: The anterior insular cortex, the region of the brain thought to be responsible for emotional feelings, was activated when a mouse’s face showed pleasure.
In the mice brains, neurons reacted with the same strength at the same time the mice “made a face.” This suggests that there are individual neurons that could be responsible for animals’ emotion, though this point requires more research.


How this could help people

“Neuroscientists don’t fully understand how emotions associated with anxiety and depression arise in the brain. Starting those studies with a mouse might give them a strong foundation.”  Learning how and where emotions originate in the brain could improve the way physicians treat people with mood disorders.


Nadine Gogolla of the Max Planck Institute of Neurobiology, neuroscientist and study author


5 comments on “Did you know . . .Mice make faces too?

  1. Why are researchers torturing mice? The results seem obvious though anthropomorphic (sp?). I get fearful when my “tail” is shocked and pretty sure a level of pleasure occurs with the 1st beer on a hot day after mowing the lawn.


    • Rick,
      I bet all the mice want to be in the mowing the lawn-drinking beer group. You would think the mice would learn to avoid people in white coats. FYI they discovered what was called the “pleasure center” working on mice, so sometimes the researchers make the mice happy.


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